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Phytochemistry and Medicinal Value of Harad (Terminalia chebula Retz.) the ‘King of Medicinal Plants’

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Terminalia chebula, popularly known as Harad, black- or chebulic myrobalan contains hydrolysable tannins. This dominantly contains many phytochemicals viz., casuarinin, chebulanin, chebulagic acid, chebulinic acid corilagin, ellagic acid, gallic acid, neochebulinic acid, punicalagin, 1,2,3,4,6-penta-O-galloyl-β-D-glucose,1,6-di-o-galloyl-D-glucose,3,4,6-tri-o-glloyl-D-glucose, terchebulin. There are many medicinal investigations recording viz., antiulcer, antioxidant, anticarcinogenic, antimutagenic, radio protective, hepatoprotective, cardioprotective, cytoprotective, antidiabetic, renoprotective, antibacterial, antifungal, antiviral, antiprotozoal, anti-inflammatory, antiarthritic, antispasmodic, wound healing and anticonceptive, molluscidal, anthelmintic, anaphylactic, hypolipidemic, hypocholesterolemic. Also having chemopreventive potential and adaptogenic activities. This has purgative property, immunomodulatory, analgesic, antiallergic, neuroprotective, acetylcholine inhibition
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A Novel Method for the Estimation of Budesonide in Human Plasma by Using LC-MSMS

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A novel method for the estimation of Budesonide in human plasma by using LC-MS-MS and the analyte is budesonide and internal standard is levenorgestreol were extracted with the tertbutyl methyl ether: n-hexane (70:30, v/v) from human plasma. The chromatographic severance was attained of the peak using Agilent Zorbax Eclipse XDB-C8 , (100 mm × 4.6 mm, 3.5 µm) column with a run time is 2.5 min. Budesonide andlevenorgestreol were recorded at the total ion current of their relevant multiple reaction monitoring. The LC-MS-MS system composed an Agilent 1100 infinity combined with an AB Sciex Qtrap® 4000 thermo Finnigan TSQ quantum discovery triple quadruple mass spectrometer. All of the parameters must be validated like selectivity, accuracy, precision, linearity, lower limit of quantification, matrix effect, recovery reached the acceptance criteria under the following of ICH guidelines. Budesonide have checked the various stability studies like short term stability at 25°C, long term stab
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Anti-inflammatory Activity of Bougainvillea glabra Linn. Flowers by Carrageenan Induced Model in Rats

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The purpose of the present study is to evaluate the anti-inflammatory activity of the fresh extract obtained from the fruits Bougainvillea glabraLinn. in rats. The fresh juice extracted from the flowers of B. glabra Linn. were evaluated for the anti-inflammatory activity by using the carrageenan induced model in rats at a doses of 100 mg/kg and 200 mg/kg respectively. Biochemical parameters like paw oedema were studied. The B. glabra contains the phytochemical constituents like steroids. The fresh extract of B. glabra flowers showed the significant reduction in the paw volume at the doses of 100 mg/kg and 200 mg/kg. The results suggest that the flower extract of the Bougainvillea possess anti-inflammatory effect. The observed effect may be due to the presence of bioactive constituents.
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Thermodynamic and Kinetic Studies for Adsorption of Methyl Violet Dye on to Creeson Seeds

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The present investigation describes the adsorption of Methyl Violet (MV) dye onto Creeson (Lepidium sativum) (LS) seeds known as Garden cress from its aqueous solution, has been known centuries ago in eastern regions then spread worldwide. The using of creeson seeds asadsorbent for the removal MV dye was investigated in aqueous solution. Effect of experimental coefficient like connection time, primary concentration of adsorbate (MV) and amount of adsorbent seeds (LS) dose and temperature were evaluated to obtain the optimum condition for adsorption of MV onto Cresson seeds using batch adsorption. The adsorption information were mathematically analyzed using isotherms of adsorption like Langmuir, Freundlich and Dubinin-Radushkevich isotherms to study adsorption mechanism of MV dye onto creeson seed. The isotherms of adsorption were advanced and equilibrium data adjusted well to Freundlich isotherm model. The studies of kinetic indicated that the process of adsorption followed the mode
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Topoisomerase an Ideal Target for Treatment of Cancer

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Topoisomerases are class of enzymes that alter the super coiling of double-stranded DNA. (In super coiling the DNA molecule coils up like a telephone cord, which shortens the molecule.) The Topoisomerases act by transiently cutting one or both strands of the DNA. Topoisomerases are enzymes that regulate the over winding or under winding of DNA. The winding problem of DNA arises due to the intertwined nature of itsdouble-helical structure. During DNA replication and transcription, DNA becomes over wound ahead of a replication fork. If left unabated, this tension would eventually stop the ability of the enzymes involved in these processes to continue down the DNA strand. Topoisomerase inhibitors are agents designed to interfere with the action of topoisomerase enzymes (topoisomerase I and II), which are enzymes that control the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle. The present review
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An Improved Process for the Preparation of Dabigatran Etexilate Mesylate and Synthesis of its Impurities

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The present invention describes the improved process for the preparation of dabigatran etexilate mesylate and impurities synthesis. TheSynthesis involves easily available commercial raw materials with Acylation from n-hexyl chloroformate makes to get desired DabigatranEtexilate from the methane sulfonic acid it is finally as a dabigatran etexilate mesylate salt with an effective yield. Catalyst free and pressure handled reactions are not performed. Dabigatran is an effective oral prodrug of the thrombin (Factor IIa) inhibitor it has been approved by FDA and is widely used to reduce the risk of stroke in patients with non-valvular atrial fibrillation.
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Design, Synthesis of New Iso-oxazoline Containing Iminothiazolidinone and its Antibacterial Activity

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We have synthesized novel 2-(4-(3a,4,5,6,7,7a-hexahydro-4,7-methanobenzo[d]isooxazol-3-yl)phenyl) imino)-3-methylthiazolidin-4-one and its benzilidine derivatives in good yields, by clubbing substituted Isooxazoline and 4-Iminothiazolidinone. All the synthesized compounds were characterized using IR and NMR spectroscopy. The results of the characterization are in agreement with the structures of compounds and testedfor its antibacterial and antifungal activity against various strains like Staphylococcus aureus (NCLM 2602), Bacillus subtilis (NCLM 2458), Escherichia coli (NCLM 2809), Aspergillus niger (NCLM 617), Rhizopus ostoyae NCLM 1299) by using antibacterial susceptibility test. All the newly synthesized compounds possess moderate to good antibacterial activity.
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