A New Process for Ciprofloxacin HCl

A single step process for the synthesis of quinoline-3-carboxylic acid was developed from 2’-amino acetophenons. With this method a Key intermediate of ciprofloxacin is prepared.

Comments

Post a Comment

Popular posts from this blog

Computational Analysis of Physico Chemical Properties of Beta Asarone

Image
The variation in the Physico Chemical properties of Beta Asarone when the temperature is raised is studied here. The Solvent effect has alsobeen calculated with 2 solvents-water and ethanol by (Polarizable continuum Model (PCM) method where a solute cavity is created by a set ofover lapping spheres and computes the energy in solution. The electrostatic interactions of molecules are studied using their Mulliken charge distribution. SCF Energy, Molecular electrostatic Potential mapping, Dipole moment, Ionization Potential and Thermal properties are also studied. Beta Asarone which is the reported toxic constituent of Acorus calamus might undergo variations with higher temperature and also when it is in solution. The study of variations in solution is challenging and here the quantum mechanical calculations are performed in two different solutions to test for any variations of Beta Asarone in solution.
Read more

Separation and Identification of the Components of Acacia Sieberiana Stem Bark Plant Extract and Study its Safety as a Treatment Drug for Diarrhea

Image
The Safety of the stem bark of Acacia Siberian, as an antidiarrheal, in Albino rats (four groups) has not yet been evaluated. Thisstudy to identify the effect of the acetone extract of the stem bark of Acacia Siberian (AESBAS) on Albino rats, Separation andidentification of the acetone extract of the stem bark of Acacia Siberian by GC-MS-TMS analysis. Albino rats (four groups) were subjected to the sub-chronic oral administration of the AESBAS for Twenty-eight days. Phytochemical screening test of the AESBAS confirmed by GC-MS-TMS analysis. Non-significant effect (p>0.05) in mean weight gain during the end of the experiment between groups. Also, some hematological analysis in the twenty-ninth day was estimated using standard steps. The AESBAS had non-significant effect (p>0.05) on some hematological analysis on study groups compared with the control group, that were given varying doses of the AESBAS. The components of AESBAS confirmed by GC-MS-TMS analysis. The results of this ...
Read more

The Influence of Fatty Acid Composition and Functional Groups on Fuel Related Properties of Sweet Almond (Prunus Amygdalus Dulcis) Seed Oil Methyl Esters

Image
The physico-chemical properties of the biodiesel prepared from Sweet almond seed oil was determined and discussed in accordance with ASTM D6751 and DIN 14214 standards for biodiesel. The influence of the fatty acid composition and functional groups on the fuel related propertieswas carried out using Gas Chromatography-Mass Spectrometry (GC-MS) technique and Fourier Transform Infrared Radiation (FTIR)spectroscopy analyses respectively. The presence of C-H indicates the presence of properties as pour and cloud point that affect the performance of biodiesel during cold weather engine operations but the biodiesel sample was found to contain more C=C that can cause it to remain in liquid state with tendency of poor storage stability. It was equally observed that the Sweet Almond Seed Oil Methyl Ester (SASOME) is mainly composed of monounsaturated fatty acid and expected to possess low values for density, viscosity, heating value and thermal efficiency with average cetane number. This woul...
Read more