An Expedient Synthesis of Ethyl 5-Acetyl-1,2,4,4a,5,6-Hexahydro Benzo- [G][1,4]Oxazino[4,3-A][1,8]Naphthyridine-5-Carboxylate from 2-Cholro-3-Formyl Quinoline

Naphthyridine derivatives have received significant attention due to their exceptionally broad spectrum of biological activity. Nalidixic acid, forexample, possesses strong antibacterial activity and is used mainly for the treatment of urinary tract infections with gram-negative pathogens [1].Close-up of Drinking GlassGemifloxacin possess both antimicrobial properties [2] whilst 1,8-naphthyridine derivatives have promising medicinal properties such as antiHIV [3], anticancer [4], anti-inflammatory [5], antimalarial [6], antibacterial [7], antiprotozoals [8], antimycobacterial [9] and antiplatelet [10]. Moreover, it was recently found that 1,8-naphthyridine derivative vosaroxin (formerly SNS-595, AG-7352, AT-3639, or Voreloxin) was found to have potential anticancer activity; it is currently subjected to clinical development. This drug is reported to exert its action via topoisomerase II inhibition [11]. Topoisomerase II is one of the well-known targets for antitumor agents like doxorubicin, etoposide, ellipticine and amsacrine [12].

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