Synthesis Characterization and Evaluation of Novel Substituted Azole Derivatives

Benzimidazole is a very stable nucleus and the derivatives of 2-methyl benzimidazole may show different and better biological activity. Thepresence of the thiazolidinone ring in a benzimidazole derivative enhances its antimicrobial activity. 2-methyl benzimidazole derivative are formed by the condensation of o-phenylenediamine with acetic acid. Combination of two or more active moieties into one is a common procedure, can result in augmenting the activity and removes untoward side effects. Hence, the present work focuses on synthesis of potent antimicrobial benzimidazole derivatives by the condensation of Schiff's bases of 2-methyl benzimidazole moiety with thiomalic acid affording the thiazolidinone ring and to study their antimicrobial activity. In antibacterial activity (Staphylococcus aureus and Escherichia coli), it shows that compound TE6 is the most active compound and in antifungal activity (Candida albicans), TE3 & TE4 are found to be most active.
Chemist, Laboratory, Periodic System, Chemistry

Comments

Popular posts from this blog

Separation and Identification of the Components of Acacia Sieberiana Stem Bark Plant Extract and Study its Safety as a Treatment Drug for Diarrhea

Reuse of Treated Wastewater of the City of Salé in Agriculture