Synthesis, Spectral, Theoretical, Antimicrobial Evaluation, and Molecular Docking Studies of Some Novel Ethyl 5-(1-Methyl-1h-Tetrazol-5-Ylthio)-4-Oxo-2,6-Substituted Diphenylpiperidine-3-Carboxylate Derivatives

A new series of heterocyclic compounds containing both N-methyl thiotetrazole (NMTT) and piperidine nuclei together, namely ethyl 5-(1- methyl-1H-tetrazol-5-ylthio)-4-oxo-2,6-substituted diphenylpiperidine-3-caboxylate derivatives, were synthesized by cyclocondensation of ethyl 4-(1-methyl-1H-tetrazol-5-ylthio)-3-oxobutanoate with ammonium acetate and substituted aromatic aldehydes. The synthesized N-methylthiotetrazole substituted piperidine-4-one derivatives were evaluated for their antimicrobial activity using disc diffusion method. The structures of the synthesized compounds were characterized by Infrared Radiation (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 (C13) Nuclear Magnetic Resonance (13C-NMR), 2D-NMR and mass spectral data. The antimicrobial activity reveals that several compounds exhibit good antibacterial activity when compared with the reference drug. Molecular docking studies were performed against malarial activities. 
Virus, Microscope, Infection, Illness, Death, Medicine

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