2-[Benzyl(methyl)amino]propanedinitrile-New Building Block for Synthesis of Riociguat, a Pulmonary Hypertension Drug

Riociguat is a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension, is prepared via an efficient, noninfringing synthesis route from commercially available diethyl malonate via [N-Methyl(benzyl)amino]propanedinitrile.
Hypertension, High Blood Pressure, Heart Disease

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