2-[Benzyl(methyl)amino]propanedinitrile-New Building Block for Synthesis of Riociguat, a Pulmonary Hypertension Drug

Riociguat is a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension, is prepared via an efficient, noninfringing synthesis route from commercially available diethyl malonate via [N-Methyl(benzyl)amino]propanedinitrile.
Hypertension, High Blood Pressure, Heart Disease

Comments

Post a Comment

Popular posts from this blog

Reuse of Treated Wastewater of the City of Salé in Agriculture

Image
The city of Salé produces about 24 millions m3 /year of wastewater. The majority of this water is discharged directly into the Atlantic coast and Bouregreg estuary without any treatment. To preserve the quality of the receiving waters. treating wastewater and reusing it in agricultureproves very interesting. The objective of this study is thus to investigate the treatment and recycling of wastewater in agriculture. We are particularly interested in studying the growth of the stem and the average number of leaves in order to prove the positive effects of reusing treated wastewater in agriculture as compared to untreated wastewater. To achieve this objective. we have investigated the irrigation of the broad bean by three types of water: Untreated wastewater (UW). Well water (WW) and biologically treated wastewater (TW).
Read more

Separation and Identification of the Components of Acacia Sieberiana Stem Bark Plant Extract and Study its Safety as a Treatment Drug for Diarrhea

Image
The Safety of the stem bark of Acacia Siberian, as an antidiarrheal, in Albino rats (four groups) has not yet been evaluated. Thisstudy to identify the effect of the acetone extract of the stem bark of Acacia Siberian (AESBAS) on Albino rats, Separation andidentification of the acetone extract of the stem bark of Acacia Siberian by GC-MS-TMS analysis. Albino rats (four groups) were subjected to the sub-chronic oral administration of the AESBAS for Twenty-eight days. Phytochemical screening test of the AESBAS confirmed by GC-MS-TMS analysis. Non-significant effect (p>0.05) in mean weight gain during the end of the experiment between groups. Also, some hematological analysis in the twenty-ninth day was estimated using standard steps. The AESBAS had non-significant effect (p>0.05) on some hematological analysis on study groups compared with the control group, that were given varying doses of the AESBAS. The components of AESBAS confirmed by GC-MS-TMS analysis. The results of this ...
Read more

Computational Analysis of Physico Chemical Properties of Beta Asarone

Image
The variation in the Physico Chemical properties of Beta Asarone when the temperature is raised is studied here. The Solvent effect has alsobeen calculated with 2 solvents-water and ethanol by (Polarizable continuum Model (PCM) method where a solute cavity is created by a set ofover lapping spheres and computes the energy in solution. The electrostatic interactions of molecules are studied using their Mulliken charge distribution. SCF Energy, Molecular electrostatic Potential mapping, Dipole moment, Ionization Potential and Thermal properties are also studied. Beta Asarone which is the reported toxic constituent of Acorus calamus might undergo variations with higher temperature and also when it is in solution. The study of variations in solution is challenging and here the quantum mechanical calculations are performed in two different solutions to test for any variations of Beta Asarone in solution.
Read more