Environmentally Benign Green Synthesis of Intermediates and their Derivatives Involving N-Alkylation of 2-Cyclohexylcarbonyl-4-Oxo-1,2,3,6,7,11 B- Hexahydro-4hPyrazino[2,1-A] Isoquinoline

Active pharmaceutical ingredient, 2-Cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11 b- hexahydro-4H-pyrazino[2,1-a] isoquinoline has been achievedby deep eutectic solvent (DES) which is an efficient, green and novel route of synthesis. This drug is used in treatment of Schistosomiasis. The Nalkylation reactions with inexpensive raw materials proceed efficiently with improved yield that makes synthesis cost effective. The present reaction offers excellent selectivity which lacks product of N, N-dialkylation. Ease of recovery and reusability of DES makes this process efficient and environment friendly. 
Lab, Research, Chemistry, Test, Experiment, Many

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