Design, Synthesis and In vitro Antimicrobial Screening of Some Novel Hybrid Coumarinyl-azetidinone Derivatives

In the present study, a series of novel 3-chloro-1-(5-((2-oxo-2H-chromen-4-yl)thio)-4-phenyl thiazol-2-yl)-4-substituted phenyl azetidin-2-ones (7a-j) have been efficiently synthesized in five steps by the use of acetophenone, thiourea, 4-mercapto coumarin and chloro-acetyl-chloride. Thestructures of all the newly synthesized analogues were characterized by 1H-NMR, 13C-NMR spectroscopy and mass analysis. All the finalsynthesized analogues were examined for their preliminary in vitro antibacterial activity against Gram-positive (Staphylococcus aureus andStreptococcus pyogenes) Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria and antifungal activity against (Candida albicans, Aspergillus niger and Aspergillus clavatus) strains by using broth dilution technique. The results of antimicrobial study revealed that some of the newly synthesized compounds exhibits potent activity against the present specific microbial strains.
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